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Old Wed Nov 9, 2016, 06:56 AM
Jacqui Jacqui is offline
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Join Date: Feb 2015
Location: Liverpool, England
Posts: 5
Can anyone interpret this bone marrow report?....

Hi, just wondering if this sounds like Aplastic Anaemia. MDs has been ruled out from a research study.

Bone marrow trephine - no megakarocytes seen, low amounts of all other cells

10% cellularity.

Bone marrow Aspirate - marrow blasts 2%
- megakaryocytes - reasonable number seen but showing low ploidy
- myelopoesis - reasonable activity but little maturation beyond myelocyte stage. Normal morphology.
- erythropoesis - reasonable number of precursors with mild dysplastic features.
- lymphopoesis - mainly normal but small lymphs
- abnormal cells - no abnormal population seen


My daughters blood counts at the moment are:
Platelets 17
Hb 11.1
Neutrophils 0.6
Lymphocytes 0.3

She also has autoimmune liver disease with cirrhosis and coeliac disease. Liver function tests are stable but blood counts steadily trending downwards. This has been going on for 5 yrs now, initially they thought it was hepatitis associated aplastic anaemia but because the counts were not severe initially, this was disregarded. Eltrombopag was looked at, but cannot be used as may cause fibrosis in marrow and also affect her liver. Drs are thinking about Atg, but again the worry is about affecting her liver. They said she will have to have a liver transplant first before thinking about a bone marrow transplant soon after.
She has just been enrolled on the 100000 genome uk project looking into rare diseases.

Anyone have any thoughts?...... The drs are at a loss on knowing what to do and what she has.


Thanks
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