Thread: MDS to AML
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Old Sat Aug 27, 2011, 11:52 AM
freedom99 freedom99 is offline
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Join Date: Jun 2011
Location: Leamington, Ontario, Canada
Posts: 40
MDS to AML

For my wife:
Changes from July 4 2011 to August 25 2011
WBC 7.4 to 37.1---- x10^9/L
RBC 3.35 to 3.16----x10^12/L
HGB 100 to 93------g/L
HCT 0.294 to 0.267
Platelet 7 to13 x10^9/L
MPV 7.0 fl to 9.1 fl
Neutrophils Relative 48.10% to 0.38.0%
Neutrophils Absolute 3.61 to 14.1 x10^9/L
Lymphocytes Relative 32.80% to 10%
Lymphocytes Absolute 2.4 to 3.7 x10^9/L
Monocytes Relative 17.30% to 1%
Monocytes Absolute 1.3 to .4 x10^9/L
Eosinophils Relative 1.5%--- toNot measured
Eosinophils Absolute .1 x10^9/L---- toNot measured
Basophils Relative .03%----to Not measured
Basophils Absolute 0.0x10^9/L-----to Not measured

Additional readings on August 25
Metamyelo.Relative 2%
Metamyelo.Absolute .9 x10^9/L
Myelocytes Relative 9%
Myelocytes Absolute 3.3 x10^9/L
Bands Relative 5%
Bands Absolute 1.8 x10^9/L
Blast Cells Relative 22%
Blast Cells Absolute 8.2 x10^9/L
Smudge Cells Relative 13%
Smudge Cells Absolute 4.8 x10^9/L

Note: Platelets are maintained at 20 x10^9/L and HGB at 80 g/L with transfusions of platelets twice a week and RBC's twice a month.
August 25 the platelet sufficiency is decreased

August 26 started on Hydrea 500mg one capsule per day

Not on any other chemo treatment except Vidazza for the months of Dec. Jan. and Feb.

Without the blast cells a week ago the doctor said that it had not progressed to AML and Hydrea would suppress the platelets even further.
Now today the doctor's nurse odered Hydrea but it seems a very low dose with may not suppress the platelets but will the low dose do anything.
With the blasts, smudge cells, bands, myelocytes and metamyelo showing up today it looks like a prosgression of the MDS into AML
Doctor said to prepare for a decline in health.
At present there are few symptons.
Have an appointment on Sept. 12
Have blood work twice a week for monitoring.
__________________
Wife 63, June 2010 MDS (refr anemia - excess blasts type-2) PLTs 11,000/μl with giant forms 2 TF/wk. Hgb kept at 80g/l with 1TF per 2 weeks. 9% blasts 2 cytogenic abnormalities del(5)(q22q35) + inv(20)(p11.23q11.21) 3 cycles Vidaza no effect. June 2011 to AML WBC to 67 blasts and Aur rods in blood.
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