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Rarity,
Yes, there can be a change from hyper-cellular to hypo-cellular, but I don't think that it is that common. Increasing LDH is a sign of additional stress in the marrow. I think that most bone marrow disorders have that as a common marker. An increase can be caused by a number of factors, including infection, but usually indicates an increase in cell destruction.
As for NRBC in the peripheral blood, they are considered blasts by my doctor, and they should not be present. RBCs have a nucleus prior to being released into the blood stream. An NRBC, is therefore one that has been released into the blood prior to maturation as a result of increased demand from the marrow. And per our friends at wikipedia:
Possible pathologic causes include anemia, myelofibrosis, thalassemia, miliary tuberculosis, cancers involving bone marrow (myelomas, leukemias, lymphomas), and in chronic hypoxemia.[4]
In addition to these, there are several other potential non-pathologic causes as well.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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