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Old Thu Sep 29, 2016, 09:19 AM
bailie bailie is offline
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Join Date: Dec 2013
Location: McMinnville,OR
Posts: 825
Thank you Debbie. This topic has particular interest for me. I believe that I developed "donor cell leukemia" (DCL) when I relapsed at about Day+210. A primary characteristic of DCL is relapsing with completely different mutations etc. than prior to SCT. My relapse (30 percent blasts and Philadelphia chromosome) was short lived. I started immediately with Vidaza and dasatinib and quickly went back in remission. DCL is felt to be grossly under-reported in the literature but now receiving considerably more attention. Many researchers now feel that donors can be carriers or have a genetic disposition of leukemia but not exhibit the disease. It is a hypothesis that it could be the reason why some people unexplainably relapse and others relapse who might seemingly appear more healthy.

You also helped answer one of my questions that I have wondered. That question was/is, "can a person have MDS/AML without having genetic mutations?" Apparently that is possible. Then I have wondered what specifically causes the higher blast count if not for the mutations? All very interesting.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.

Last edited by bailie : Thu Sep 29, 2016 at 10:35 AM.
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