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I think you should give cyclosporine more time. It takes a couple of months for it to build up in your system. Cyclosporine isn't as strong as ATG, yet people usually have to wait 3-9 months for a response to ATG. So, it seems like you should give Cyclosporine at least that amount of time to work. The fact that the length of time between transfusions increased is a very positive sign, in my opinion. I wouldn't want to lose that by stopping the drug prematurely, if he is tolerating it well. I am not a medical expert. These are just my thoughts.
Something also to consider is ATG given at a lower/slower dosage over 10 days. I remember reading a paper about this in the past as an option for older patients. I will try to dig it up....
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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