[Hopeful]

Hi Meaghan,

Your initial presentation was very similar to mine.

My local hematologist was for stopping cyclosporine at 6 months. However, I also consulted with another specialist who saw a LOT more aplastic anemia patients. He recommended that I didn't even consider tapering at 6 months while my counts (like yours) were on a slow but stable rise. His recommendation was to stay on cyclosporine until my counts were stable for 3 months and then to taper very slowly at 25mg every 3 months. I did drop my dosage significantly at 6 months from 12mg/kg/day to a more reasonable 5 mg/kg/day with no ill effects because I *felt* the dosage was toxic for me. There are no solid guidelines on cyclosporine for bone marrow failure diseases. However, there seems to be a lot of research stating that 6 months is too early to stop and that a rapid taper is not advised.

What is your current cyclosporine dosage in mg/kg/day?