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There are different protocols for ATG/cyclosporine.
I was on an older protocol with the cyclosporine dosage at 12 mg/kg(body weight)/day while taking ATG. This was lowered shortly after I left the hospital. The "older thinking" was to give the maximum cyclosporine that the body can tolerate.
Some of the newer protocols consider 5 mg/kg/day the maximum upper limit to take to avoid organ toxicity. The "newer thinking" is that more-is-not-better. Instead it is preferred to give the minimum cyclosporine dosage that is still effective.
You will find doctors in both camps. Unfortunately, there are no definitive guidelines for the drug in the treatment of AA/MDS.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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