Quote:
Originally Posted by sbk007
I don't think you can test for the protein before transplant. I think after transplantation they can test for it as an early indicator. That's the way I read it.
Not only is there t-cell depletion controversy(because although you might avoid gvhd, it might increase the risk of other things) but also the method used to deplete the t-cells is controversial. There's one drug called Prochymal that's approved in CD but I cant find much info on the clinical trials here.
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This is exactly what happened to my husband The protocol that took place after transplant was to decrease his risks of GVHD. It is what I would deem over the top and caused his organ failures and damage to the donated cells causing the clotting disorder. I do not feel they know enough to protect our loved ones from the critical complications that arise after HAPLO the immune system is compromised for such a long period of time that it becomes a race to have the patient graft and begin to grow a immune system before complications become life threatening.
Seek as many opinions as you can in making the decision to move forward with the HAPLO.