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We must get the right medicine, the right dose, or just have a great anesthesiologist.
When my wife has had conscious sedation for a bone marrow biopsy, it's been with propofol (trade name Diprivan) and it has worked beautifully. It's the same drug that Michael Jackson overdosed on, but used correctly.
It's as if the anesthesiologist had flipped a switch. One minute my wife is talking to me, then she's out cold in seconds, and when the anesthesiologist wakes her up afterwards she asks "did they do it yet?" She has had no side-effects or after-effects, unless you count the higher bill (covered by our insurance).
I hope every institution learns to administer conscious sedation this well for those who need it. It's total anesthesia, not a topical painkiller, so you must have an anesthesiologist, not just a nurse.
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