2064 Combination of Two Orally Active Iron Chelating Agents: Efficacy and Safety In a Clinical Setting
http://ash.confex.com/ash/2010/webpr...aper31685.html
Citation: "The combination of DFP and deferoxamine (DFO) has been shown to be effective in reducing cardiac iron overload but some patients are unable or unwilling to use DFO. DFP alone has also been reported to be cardioprotective."
So 4 adult patients with thalassemia major with major problems with excessive cardiac iron load, a reduced left ventricular ejection fraction and either severe allergy or intolerance to DFO have been treated with the combination of DFX and DFP for between 6 and 60 months (mean 18 months). The frame was a compassionate-use programme.
The compliance of the patients was not very high, and so the results vary. The results" "indicate that the combined use of the two oral chelators (DFP & DFX) prevented further cardiac iron loading with a tendency for its reduction, significant improvement in left ventricular ejection fraction, maintenance of ferritin levels and LIC."(..) "The combination was well tolerated and easier to manage."
Citation "In particular, a prospective randomized study in patients with excessive cardiac iron will be necessary before this combination could be considered standard therapy."