Thread: azacitidine
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Old Mon Mar 9, 2015, 06:18 AM
DanL DanL is offline
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Join Date: Dec 2010
Location: Denver, CO
Posts: 590
Faye,

I am sorry to see that you have had some difficulties with Vidaza. The dose reduction is somewhat individualized based on your needs, but are also addressed by the protocols of the manufacturer, and takes into account blood counts and recovery times. with such low neutrophils, dose delays or reductions may make sense, or there is also the possibility of adding GCSF, or potentially antibiotics to your regimen for when your white counts are so low.

My recent treatment with Vidaza would knock my white blood counts down from the mid 3s and 4s to as low as .50 during the 3rd week of administration, and would also knock my platelets down from the 120k range down to the 25-30k range before recovering the next two weeks.

It does seem that everybody has a slightly different response to Vidaza. The first time that I took it about 1.5 years ago, I did not experience the same level of marrow suppression, but also only finished two rounds.

Lastly, ideal dosing that is tailored to a patient may take some time. Both Vidaza and Dacogen have had a few clinical trials where the doctors have stretched out the dosing over 10 days or 14 days - taking less for more days - with success rates that are still pretty good, but maybe less toxic to the right patient.

Wishing you strong and well.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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