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EPO+Gcsf in hypercellular marrow
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Originally Posted by MDSPerth
I understand that these types of medication are not commonly used in patients with hypercellular MDS as there are suggestions that it might increase the blast cells.
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MDSPerth, thanks for responding and highlighting the marrow connection.
My mother has hypercelluar marrow. I have not found any study where there is reference to the marrow(hyper/hypo) in regards to response or use of growth factors. I have read threads on this forum where Gcsf has not been prescribed due to fear of increasing blasts but again not found any studies on this or in connection with hypercelluar marrow.
As I understand, EPO alone and with addition of Gcsf is the first line of treatment of anemia in low risk MDS.
I am worried about the increase in blasts and hypercellular marrow. Is it going to be a big risk?
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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