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Thank you, Tony, that is interesting to know! My son had dark urine and a high bilirubin level for the week following ATG. They tested his urine at the next visit but his urine was getting normal colored by then. Based on his hemoglobin levels he didn't seem to be having hemolysis, but it definitely could have been him shedding some PNH cells after ATG (which would be hopeful!). He did have significant hemolysis once after a platelet transfusion. At the end he mottled all over - the mottling continued on and off for two days and in the matter of four days his hemoglobin went from the 9s into the 5s (which is a fast loss for him). They thought it was a case of secondary cold agglutinin brought on by his high level of lymphocytes on that visit (90%) which it certainly could have been, but it could have been the PNH, also. Luckily it's been the only time he had a reaction to a blood or platelet product and showed any hemolysis.
Take care and good luck with K's tratment!
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