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Originally Posted by rukalukavina
So, today I got this diagnosis. I'm pretty confused.
I know that MPN stands for myeloproliferative neoplasms, but what does Anaemia grav. MPN. Ph- actually means? Is this a transition to MDS or some kind of leukemia?
Please, anybody who knows for sure what this actually is I would appreciate any help.
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I don't know the terminology that doctors in your country use, but my guess is that "anaemia grav." means that you are seriously anemic (lacking red blood cells) and that "MPN. Ph-" means that you have a myeloproliferative neoplasm that has been found not to have the "Philadelphia chromosome" problem.
As you've probably read, MPNs are a range of bone marrow diseases characterized by excess numbers of cells. What it means for you depends on the specific classification. The "Philadelphia chromosome" is a particular genetic problem, where genes of chromosome 9 and chromosome 22 have changed places, that is useful in classifying MPNs. Having the Philadelphia chromosome problem (being "PH-positive") strongly correlates with having chronic myelogenous leukemia (CML).
You are PH-negative, so you have a different classification and not CML, but they haven't yet told you (so they may not have determined) which PH-negative classification. That's the next thing you'll want to know, since that will determine the treatment you might need and the overall prognosis.
One PN-negative MPN is polycythemia vera (PV, characterized by red blood cell overproduction). Another is essential thrombocytosis (ET, characterized by platelet overproduction). A more serious PH-negative classification is primary myelofibrosis (PMF), with overprodution of stems cells in the bone marrow. I hope they can narrow down your diagnosis soon.
You asked about MDS and leukemia. The connection to these other bone marrow diseases is that MPNs can sometimes evolve into myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML).