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Paul,
When you say that the vidaza didn't work, are you referring to pre-transplant? There is not a whole lot of research that has been published on relapse and the use of vidaza, especially in early relapse as opposed to full blast crisis. Here are some possible reasons to consider it if your doctor sees the need for treatment...a transplant replaces your marrow with somebody else's - meaning that it may respond differently, the nature of a relapse may be different than the original disease, and lastly, it is possible that all your new marrow needs is a booster shot, or additional support to knock out any bad cells.
In my case, i had 2 or 3 cycles of vidaza pre-transplant and i did not really see any positive results, just rapidly dropping blood counts and increasing blasts. Post transplant, I had 6 cycles of treatment with vidaza, and saw my platelets increase in the first cycle, with whites and reds following, so the response was 180 degrees from the first time around.
Hopefully as you and your doctor noted, it is just a blip and does not require anything more than patience.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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