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Old Sat Dec 17, 2011, 09:51 AM
Lbrown Lbrown is offline
Join Date: Oct 2009
Posts: 361
Vitamin D Receptor Agonists in the Treatment of Autoimmune Diseases

This is a good article about the use of VDR agonists to treat autoimmune disease:

The treatment I'm on uses olmesartan as the VDR agonist, and you limit your blood levels of vitamin D to reduce the level of the hormone 1,25D (short for 1,25(OH)2D3). It is replaced by olmesartan which binds into the VDR.

When I had my vitamin D measured, my serum vitamin D was low, but my 1,25D (the active metabolite) was high. It is not common to test for 1,25D, which is why very often people have low vitamin D and are considered vitamin D deficient. If they tested for the active metabolite it could show otherwise. The theory is that most people with AI disease seem to be D-deficient, but it is a result of and not the cause of the disease, and is dysregulated in AI disease.

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