Hi Freedom,
You know I only accepted supportive care for example txs the first 4 your of my disease of the same reason as you mentioned - I felt fine and didn't want to get a drug that caused nausea, fatigue and perhaps other adverse effects.
When I needed txs every week and hardly dared to cough because I was afraid of stroke due low platelets I changed my mind and started with Thalidomide with good result and no adverse effects.
In Sweden we don't have a tradition of liability issues so our doctors can prescribe Promacta (called Revolade here) or Nplate if they think the drug will help the patients and I suppose it's the same in Canada.
Even if the BMB didn’t show any change I think your wife should have continued with Vidaza – all studies show the same: response can come late.
http://www.ncbi.nlm.nih.gov/pubmed/21225870
Kind regards
Birgitta-A