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Old Thu Mar 17, 2016, 05:48 AM
Ashleigh K. Ashleigh K. is offline
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Join Date: Jan 2016
Location: Birmingham UK
Posts: 21
Quote:
Originally Posted by Hopeful View Post
Hi Ashleigh,

I had to look up your chromosome abnormality, as I have never heard of one described like this before! I also have a chromosome 6 abnormality, so I was extra curious.

From what I read, you had some new SNP-arrat karyotyping done that detects the cryptic chromosome abnormalities in people that were previously thought to have "normal cytogenetics"

I found a couple of articles that may interest you. You will find that you-are-not-alone This abnormality seems to be characteristic of an immune mediated attack and may go away with remission.

Here are the articles to check out:

https://ash.confex.com/ash/2014/webp...aper75445.html

http://www.ncbi.nlm.nih.gov/pubmed/26702937

http://www.hematology.org/Thehematologist/Ask/4351.aspx
Thanks for the articles Hopeful! The last one was a very interesting read.
From what I can understand, the chormosomal abnormality in chromosome 6 is the body's way of "escaping" the immune attack on the bone marrow, I think
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Diagnosed AA in 2009;treated rabbit ATG+Cyclosporin the same year, taken off Cyclosporin in 2011; Relapsed AA in 2015 and had horse ATG as of 08/02/16. I have copy neutral loss of heterozygosity in chromosome 6p, affecting the HLA region.
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