[Hopeful]

Clairekim,

I am sorry to hear that your wife didn't respond to the second round of ATG.

I recall that when I was transfusion dependent, I had HLA testing done before each transfusion and that the donor's blood products were always cross matched. They needed to check my blood every time because with each transfusion comes the possibility of new antibodies. They always cross matched the donor's blood with mine to ensure their compatibility.

If the blood bank wasn't doing the type and cross before each transfusion, perhaps that is another contributor. If there is no type-and-cross, the blood bank mixes together multiple peoples' platelets into her one bag for transfusion.