Thread: Copper levels
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Old Thu Feb 4, 2016, 03:06 PM
curlygirl curlygirl is offline
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Join Date: Jun 2013
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This is not about MDS but sideroblastic anemia, however the reason for the sideroblastic anemia was that 13 people were taking high levels of zinc for long periods, resulting in copper depletion, which resulted in "anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts". So while the woman in your second article (the original I read) had a copper absorption problem, if you take a lot of zinc it can be causing the same low copper problem.

http://onlinelibrary.wiley.com/doi/1...60217/abstract

Abstract

Zinc ingestion has become increasingly popular in the lay and food faddist population. Herein described by way of a case report and review of the 13 cases in the literature is the syndrome of severe anemia associated with excessive and prolonged intake of oral zinc. The syndrome is characterized by anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts. Serum analysis reveals increased zinc levels, decreased copper levels, and a decrease in ceruloplasmin. The mechanism appears to be zinc-induced copper deficiency, which is instrumental in producing the profound bone marrow abnormalities, as zinc itself is of low toxicity. Importantly, the syndrome is totally reversible with cessation of zinc intake. Hematologists should be aware of this form of reversible sideroblastic anemia.
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