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Dhruba, the first thing you need to do is have your wife's sister tested.
BMTs don't happen quickly, it will take time to do the testing and make all of the other necessary arrangements. Since she has already been taking cyclo since September, 3 months is not that far off. Even if her sister is a match, I doubt they could arrange to do the BMT before then, and if she shows improvement by then, you can always cancel it. You are not committed to go through with any procedure if her circumstances change. The doctors should tell you that.
Yes, the more transfusions she has, the more risk of developing antibodies that can complicate a BMT. That is not a reason to avoid transfusions, however. To not get needed blood or platelets would be much riskier for her health in general. It is unavoidable, but there are many people here who have had quite a few transfusions and still had successful BMTs.
It might help you to read the transplant section of this forum, just to get a better idea what is involved.
All the best,
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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