[PaulS]

The chimerism went from 100% donor to around 50% - dysplastic cells and blasts 4% also showed up. My disease was also associated with painful hive like skin nodules (Sweets Syndrome?) - they went away after the transplant, but came back with a vengeance. My blood counts also started dropping fast (last Hgb was 5.2, platelets 10 - WBC equally alarming, but the chemo probably had something to do with how low those counts were). They did not find any genetic abnormalities. I have another BMB coming up and it will be interesting to see if there has been any changes. The skin nodules are much improved - maybe from the AZA and Veneteclex - but not so much to think another transplant can be avoided. There is still a slight hope the drugs will have worked better than we think - but the chance of avoiding another transplant is pretty low - but not zero.

It all started with chimerism dropping to 85% and .09% blasts showing up - at that point we hoped it was just an anomaly - next BMB and CBC unfortunately was much worse.

Your relapse seems really unusual - its great you're doing so well. I found AZA fairly difficult - a lot of pain and fatigue. Fatigure might have been from low HgB - but the pain was around the injection sites and other muscles and joints.

Stay well!

p