[clairekim]

Hi there.

My wife Claire, too, relapsed after successful ATG + Cyclo treatment back in 2011. Back then, her counts moved quickly but did take upto a full year before reaching normal levels.

She relapsed in Oct 2014. She had another Horse ATG + Cyclosporine. We also added Eltrombopag this time. However, unfortunately, we haven't yet seen a robust response. After 4th month, her counts moved a little. She stayed transfusion independent for 2 months now, but her counts steadily moved downward again. And here we are today at MDAnderson in Houston, getting prepared for transfusion again.....

We are now seriously considering BMT. She only has 9/10 donor. So we are meeting with doctors at NIH next month, hoping there's a good clinical trial for us. Specifically, we are interested in haplo BM + Stem Cell co-infusion transplantation trial.

The odd thing is that Claire's latest bone marrow biopsy showed >40% cellularity and her Retic count is now in normal range. Yet her CBC counts are not moving in the right direction.....

Good news...she doesn't have any signs of clonal evolution.