Hi,
Do you have or think you might have PNH? I hope not. In the case of PNH the clone is an mutation which often occurs in the setting of Aplastic Anemia. Many with PNH got AA first but most people with AA do not have PNH. There are fewer people with both MDS and PNH.The size of the clone is measured by flow cytometry (done by simple blodd draw). A 25% clone for example means 25% of the white blood cells, also called granulocytes, are PNH affected cells.
When you saw monclonal antibody it may have been describing Soliris, one of the treatment options for PNH. Soliris blocks a part of the immune system which is involved in attacking the red blood cells. Sorry not a scientist but for more explaination on PNH take a look at this PNH overview article, about the best around, Diagnosis and Management of PNH:
http://bloodjournal.hematologylibrar...06/12/3699.pdf
suz