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Old Fri Feb 5, 2010, 12:02 AM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Vicid,

I am sorry to read of you and your father's struggles.

Here is a good article on the treatment of MDS with ATG:
http://www.nature.com/leu/journal/v1.../2403124a.html

I was told that age under 60 years old was one of the better predictors of response to ATG. I am not sure why this is.

I've heard of a European protocol using rabbit ATG at 3.5 mg/kg/day given over 6 hours for 5 days. This may be what your father got and may explain why there was "something left in the bag".

Be sure that the doctor's are checking your father's cyclosporine levels and that the trough levels are not exceeding 400, whatever brand of cyclosporine that he is using.

I would talk to your father's doctors about starting chelation therapy for iron overload if your father has had over 20 units of packed red blood cells.

Please try and get another opinion on how to proceed. It seems like something is still going on if your father is requiring 2 RBC transfusions a week
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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