I should correct my above post and say that 12 weeks was the point when an initial response was evaluated and that after 16 weeks the Eltrombopag was stopped if no response.
Here are the dosing notes from the maker of Eltrombopag, just as another reference point:
https://www.gsksource.com/pharma/con...G-COMBINED.PDF
I am no expert, but you may want your husband to have his cytogenetics checked if remaining on the drug for an extended period of time. Cytogenetic changes seems like one of the bigger unknowns/risks with this drug.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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