Hi SallyC,
The uneasiness that I have heard concerning Eltrombopag, and why researchers are still encouraging that it only be used within a clinical trial, is because they now think that some patients may have a small monosomy 7 clone or other cytogenetic abnormality, undetected at diagnosis, that may be stimulated to expand by this drug.
Here is a very recent interesting article from the New England Journal of Medicine in which Dr. N. Young and Dr. P. Scheinberg talk about these concerns.
http://www.nejm.org/doi/pdf/10.1056/NEJMc1209254
I think that it is a very good sign that your husband's cytogenetics have remained very stable 
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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