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Old Thu Oct 25, 2012, 04:01 PM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
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Quote:
Originally Posted by Lisa V View Post
Since ATG is designed to target the T-lymphocytes, wouldn't you want them to be low following treatment? I realize there are other lymphocytes besides the T cells, but I'm not sure what the percentage is. Anyone know?

Here is a recent article from Blood that talks about this. It says:

"Horse ATG is considered moderately lymphocytotoxic through the action of polyclonal Abs that produce transient lymphodepletion (usually 1-2 weeks duration) and longer elimination of activated T cells, which are assumed to contribute to the induction of tolerance. Rabbit ATG is more efficient at depleting peripheral blood lymphocytes in vivo and is more cytotoxic on a weight basis in vitro."

http://bloodjournal.hematologylibrar...119/2/345.long
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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