Hi Anne,
Dacogen should give hematological improvement in 73 % of the patients. You know often it takes several cycles before Dacogen or Vidaza have a positive effect. The adverse reactions come at once and low red blood cells, white blood cells and platelets are common (Vidaza has the same adverse effects).
http://www.pcpoh.bham.ac.uk/publiche...Decitabine.pdf
As far as I understand many patients need packed red blood cell and platelet transfusions when they start treatment. When the white blood cells are low the patients should have Neupogen or similar treatment.
Look out for infections!
Kind regards
Birgitta-A
69 yo, dx MDS Interm-1 May 2006, transfusion dependent, Desferal 4 days with transfusions, Neupogen 2 injections/week, asymptomatic