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Old Sun Mar 5, 2017, 11:47 AM
Neil Cuadra Neil Cuadra is offline
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Join Date: Jul 2006
Location: Los Angeles, California
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Quote:
Originally Posted by mahendra_413 View Post
Asper the discussion with doctor his neutrophils are normal.
That is excellent news!

Quote:
Do this mixed chimerism shows marrow rejection( elapse)?
This article from researchers in India says that low levels of persisting recipient cells are not always associated with an increased risk of relapse. They are talking about leukemia, but I presume that this applies to other post-transplant chimerism. They say that the bigger concern is when the level of recipient cells increases over time (called progressive mixed chimerism). So the next chimerism test will be an important measure.

That report also states that "On one hand there is the belief that there is a strong correlation between relapse and hematopoietic mixed chimerism, while on the other hand there are reports which show no such correlation."

A more recent article confirms this, saying "Studies examining the predictive ability of percent chimerism have produced conflicting results." They were studying leukemia and MDS patients.

Your concerns about relapse are understandable, but I doubt that anyone can give you a precise measure of the chance of relapse. Even when transplant recipient cells remain, they could be damaged cells that survived the pre-transplant conditioning or they could be healthy cells with no associated risk.
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