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Old Tue Mar 20, 2012, 05:59 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Dacogen

Hi Cheri,
Hope you will get info from Dacogen users.

Here is some info from the package insert from Dacogen that Greg posted:
First Treatment Cycle
The recommended Dacogen dose is 15 mg/m2 administered by continuous intravenous infusion over 3 hours repeated every 8 hours for 3 days. Patients may be premedicated with standard anti-emetic therapy.
Subsequent Treatment Cycles
The above cycle should be repeated every 6 weeks. It is recommended that patients be treated for a minimum of 4 cycles; however, a complete or partial response may take longer than 4 cycles. Treatment may be continued as long as the patient continues to benefit.

In many studies they now administrate Dacogen like Vidaza during 5 days/month because the initially used dose probably was too low.

The adverse effects are among others:
Neutropenia 90%, Low platelets 89%, Anemia 82%, Anorexia 16%, Joint pain 20%, Pain in limb 19%, Back pain 17%, Headache 28%, Insomnia 28%. Patients treated with Dacogen were compared with patients treated with supportive therapy and these patients often had these symptoms too.
Kind regards
Birgitta-A
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