|
Analyse of Dacogen/Epival responders/nonresponders
Hi Ed,
You know I spend at least 2 hours every day at my pc looking at posts from 5 support groups, about 20 Google alerts (drugs) and about 20 drug companies. Then about once in a week I look at PubMed and clin trials gov. Once a year I follow the 4 most important conferences. I use the same type of coping as you do – it is important to be informed about our disease.
Today I found an interesting abstract from MD Anderson Cancer Center about response in patients treated with Dacogen (decitabine) with and without Epival (valproic acid) where the researchers could see already at day 5 which patients that were responders.
They looked at hypomethylation of miR124a1 (one of the MicroRNAs – small RNA molecyles regulating which genes are expressed) and hypomethylation correlated with response.
This type of info is very important for us because today many patients are treated with drugs without response for many months and we know that only about 50% of the patients will respond.
Kind regards
Birgitta-A
|