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Thank you Relentless. My niece started to taper cyclosporine about 8 months post ATG and the taper completed in about 4 months’ time. About 4 months after taper completion, her platelets dropped to about 20k-25k and then 15k -20 k range. Platelet transfusion still not required but re-started RBC transfusion. She resumed cyclosporine since March 2013 and became transfusion independent for 8 months and needed RBC transfusion again in Jan 2014.
Our doctor said whether it is stem cell or bone marrow transplant depends on which collection method the donor will choose. Doctor did not mention about the expected outcome of B mismatch, but they seem not too concerned. Also has not mentioned any difference in handling the transplant compared to 8/8 match (we do not type for DQB1 and hence the best possible match is 8/8). Thanks for reminding. I will raise the questions in our next appointment.
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AAteen, niece dx moderate AA early 2009;ATG in mid 2010 with partial response;currently on cyclosporine; cytogenetic abnormality of trisomy 8 found in early 2014
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