Hi AATeen,
Since your niece does not have a sibling match and responded to the initial ATG (as well as a restart of cyclosporine), I think that you should discuss with her doctor trying a second round of ATG. It may be that the cyclosporine alone is not strong enough to combat the immune attack. Trisomy 8 is a sign that an immune attack is going on.
A second round of ATG is the accepted protocol in the US for someone without a good match that had a response to ATG the first time. People do respond to the second round of ATG, including some people on this forum. Don't delay!
Best of luck!
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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