[tytd]

Hi Chris, I can't really answer the question about cyclosporine and decreased platelets but many of these therapies tend to make the counts worse intially before they start climbing. Simplistically thinking, I guess this happens because the initial bad MDS clone cells that are manufacturing the dysplastic cells are knocked out first before the good normal stem cells can take over again. Since I am a "watch and wait" type of person, I wondered why the docs wanted to initiate therapy without first watching the trend in your mother's counts for a few more months. Did she have a critically low neutropenia or was she having frequent infections or bleeding?? I am just curious since she is in the low risk category ( but maybe she had a high MD Anderson score). I hope the platelets will start moving up soon. Good Luck tytd