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Lisa,
Very interesting question about the Trisomy 8. My first BMB, which included Karotype but no FISH, found no Trisomy 8. A couple of months later, my second BMB included FISH, and that found 5% Trisomy 8, which still didn't show up in the karotype. Six months later, the Karotype showed Trisomy 8 (15%, I think), and, over the course of a year, that percentage went as high as 85% before disappearing in my most recent BMB.
The work that Elaine Sloand did at NIH on Trisomy 8 showed that the body can create a subpopulation of T-cells aimed at Trisomy 8, but also seemed to show that Trisomy 8 cells can continue to generate viable blood cells.
It's a great mystery: the bone marrow.
Take care!
Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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