Hi King Farouk,
Good that your father didn’t have any adverse reactions to Dacogen
!
You know we can manage quite well with cytopenias with packed red blood cell transfusions, Neulasta and Promacta for the three cell lines.
There are more reports from trials in MDS patients with Nplate than with Promacta. Here is one of them:
http://ash.confex.com/ash/2009/webpr...aper19357.html.
The drug can increase blast cells. FDA has a special warning about Nplate (page 11):
http://www.accessdata.fda.gov/drugsa...8s000_sumR.pdf
There are two trials with Promacta in MDS patients and the first one will be completed during the fall 2009. Otherwise there are only trials in tubes. This study shows that Promacta can decrease leukemic cells:
http://www.ncbi.nlm.nih.gov/pubmed/19710504
Both drugs can increase bone marrow fibrosis.
If you search at Raza at Marrow forums you will find a lot of posts (very positive) about Dr Azra Raza.
Kind regards
Birgitta-A