It is my understanding that the excitement around Eltrombopag is when it is used *in combination* with ATG. I haven't read or heard anything about its effectiveness when used alone. This is likely because the immune attack must still be stopped.
A good predictor of response to immune suppression from NIH is the level of ARC or ALC. Having ARC levels above 25,000 or ALC levels above 1,000 increases the probability of a response (60-80% vs 40% with low ARC/ANC).
I remember reading a paper about using a lower dose of ATG over a longer length of time for older patients. I posted it in this forum before but will have to dig it up.
Here is a great presentation out of Europe on treating older patients with AA that I found. It discusses using Cyclosporine alone, ATG success with older patients, and low dose ATG:
https://www.ebmt.org/Contents/Resour...helliFinal.pdf
Good luck!