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Hi Ziad,
I think you made the right decision about Exjade for now. There's very little good research that shows iron overload affects survival in older MDS patients. Perhaps, once your father's blood counts stabilize, you will have an opportunity to worry about Exjade.
Eprex is a synthetic version of EPO, a chemical produced naturally by the kidneys that stimulates the bone marrow to make more red blood cells. Patients who already have a high level of EPO are less likely to respond to Eprex. Perhaps this was the case with your father. Most patients who do respond to Eprex eventually stop responding, but usually after three or four years rather than three or four months.
Are your father's doctors suggesting other drugs? Did he already try Vidaza or Dacogen?
Take care!
Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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