[evansmom]

My son had a 9/10 mismatched BMT and had zero complications as a result. It is, however, VERY important that the doctor discuss with you WHERE the mismatch is located.
For a simplified example, a mismatch on A,B or C can have much more serious potential complications (graft failure, graft vs. host) than a mismatch on DRB1 or DQB1. To complicate matters, it can also make a difference in terms of whether the mismatch is on the alelle or the antigen.

There has been much research on BMT outcomes as a result of specific mismatches and hopefully your doc can explain the potentials as it relates to your situation.

So having said all of this, it is actually possible that the 8/10 donor BMT may carry less potential risk for unfavourable outcome than the 9/10.

Evan's donor was mismatched on the alelle of DQB1 and was A+, while Evan was O+ and just as predicted in studies, Evan's only issue was slightly prolonged engraftment of the red blood cells.

Hope this helps and best wishes,