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Hi Tony,
I am the same weight as your wife and was on the same protocol. I think it was from 1992! I was originally on 575 mg/day, and it wiped me out every time I took it. My local hematologist was concerned with hitting the magical trough numbers, but I metabolized the drug so quickly that even on the higher dosages, I couldn't do it.
Luckily, I consulted with another expert who said to ignore the trough, unless I was concerned with toxicity, and just use 5mg/kg/day.
200-250 mg/day was a much saner dosage for me, and it worked. Karin will likely be able to resume the cyclosporine after her kidneys recover. As a side note, I've read different papers that say taking magnesium with cyclosporine helps the kidneys.
More is not better with cyclosporine. Unfortunately, a lot of doctors still follow that old protocol.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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