[Neel]

Hi ppl,

Just went thru the literature with Neupogen injection. It says that neupogen is not recommended for MDS. Also it stated that neupogen may increase the blasts cell (progress the disease). Applied my mind and the below are my observations :-

1. neupogen is a growth factor. It promotes or stimulates the bone marrow to produce more white cells, irresepective of whether they are healthy cells or blasts cells. if such is the case then definately it will increase the blasts cells.

2. neupogen does not differentiate between the healthy cells and blasts cells, therefore whatever efect (stimulation in bone marrow) to produce more white cells, it will have same effect on healthy cells as well as blasts cells.

3. If the abiove is the case, is it adviseable to take neupogen specially :-

a) when ur blats percenatge is already high ?
b) when you are not having any infection, just for precautoinary sake, is it advisable to take neupogen ? Means one takes neupogen so that its WBC increases so also its neutrophil counts so that there is less chances of infection, but infection is not dependent on neutrophil counts alone. A healthy person with enough WBC and neutrophil counts also catches infection. So its the fear of catching a infection which drives a person to use neupogen, but when it can/do increases the progress of the disease by increasing the blasts cell, is it advisable to take neupogen ?

regrd,

Neel
c)