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Old Mon May 6, 2013, 04:12 PM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Curcumin

Hi Deb,
Curcumin seems to be a drug that has a lot of effects. For MDS patients these two effects are important - it is supposed to be DNA hypomethylating like Vidaza and a histone deacetylase inhibitor (HDAC inhibitor) like Vorinostat.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572185/
"A variety of molecular mechanisms have been proposed to mediate these effects, and other groups have reported that curcumin acts as a scavenger of free radicals, an inhibitor of NF-κB nuclear translocation, and a modulator of histone deacetylase (HDAC) and histone acetyltransferase (HAT) ......curcumin and its analogs may inhibit enzymatic activity of DNA methyltransferase."
Kind regards
Birgitta-A
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