Hi Kgtuck,
You know Dacogen (decitabine) doesn't have effect at once but it often takes several cycles before the response. This depends on that Dacogen (and Vidaza) require DNA replication for their function.
http://www.plosone.org/article/info%...l.pone.0017388
That means that if you stop take Dacogen it will take some time before your counts will decrease but probably it isn't a good idea to try this - it can perhaps increase the risk for Dacogen "resistence".
Hi Lifeguard,
Yes, I have read several reports where they mention that there are patients who respond to Revlimid or Thalidomide late (after the study is finished) and that patients who have to stop taking these drugs due to adverse effects can continue to respond several months. I should not try to change my dose if I didn't have adverse effects.
Good that you both have so positve results with the medication
!
Kind regards
Birgitta-A
72 yo, dx MDS Interm-1 2006 with all counts low, Thalidomide + Prednisone since June 2010 with good response , latest counts HGB 13.5, WBCs 5.1 and platelets 88.