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That does sound like a really high dosage, Hopeful.
Ken has had to lower his dosage several times. Since he's now several years post-ATG we're not too concerned with trying to maintain a therapeutic level, just a maintenance one, and 175 mg/day (roughly 2.25 mg/kg, if my math is right) allows him to keep his creatinine between 1.1-1.3, assuming he drinks LOTS of water. He takes Gengraf, generally with meals, but is not terribly strict with timing, etc. If he slacks off the water intake, though, or if the weather gets particularly hot and humid, the creat starts creeping up again. It was 1.0 when he was first admitted, so we're happy if he can keep it around 1.2.
He doesn't get CSA readings that often, but his trough levels when he was on 200 mg/day (2.55 mg/kg) ranged between about 80 and 180, and at the 175/day rate it's been between 50 and 80.
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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