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Rebecca,
I had pretty low cellularity for quite some time and pretty low blood counts across the board for several months after transplant. I had moderate to severe fibrosis at the time of transplant, experienced a minor relapse, and had several other issues for quite a while. I was treated with Vidaza and Rituxan, and actually saw an improvement in numbers after two days of Neupogen one time when I was hospitalized.
The thought was that I had some element of relapse, but was also experiencing systemic GVHD that was possibly suppressing the recovery. My cellularity increased and is normal now, and I have normal RBC and WBC, with platelets that hang out between 100k and 150k.
We didn't have any real conversation about stromal cells or damage to them at the time though.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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