Hi cheri,
It is true that Exjade can give more serious adverse reactions in MDS patients:
http://www.fda.gov/Drugs/DrugSafety/.../ucm183651.htm
Still iron overload in MDS is an indication for the drug. As far as I understand MDS patients have a much more severe disease than other groups of patients with iron overload like thalassemia patients - they have an inherited disease where the red blood cells don't function and no bone marrow disease.
As long as we look out for adverse reactions like creatinine increase due to kidney damage I think we should continue with Exjade. There are a lot of studies showing positive effect of Exjade in MDS patients.
Kind regards
Birgitta-A
!42 units of PRBCs. Exjade (low dose due to low WBCs) since 2009