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Old Wed May 21, 2014, 11:25 PM
marmab marmab is offline
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Join Date: Jul 2011
Location: Massachusetts
Posts: 67
Thanks for both of your replies. You're right that most transplants use PBSCs. But I was under the impression that for aplastic anemia, marrow is still preferred, as studies show a smaller incidence of chronic GVHD when marrow is used, vs. PBSCs. The reason that you rarely hear of marrow being used may be that there are, in number, relatively few transplants performed for aplastic anemia (a rare disease), compared to transplants for blood cancers, MDS, etc., especially in older adults.

Also, there is no doubt that, for the donor, marrow donation is more onerous than PBSC donation. And yes, with women donors, pregnancies are the issue.
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Marmab, F65, SAA/hypo MDS dx 7/2011. Tried ATG/CsA, IvIG, Rituxan, prednisone, Promacta -- none of these helped. Transfusion dependent until MUD BMT 7/17/14. Prep. regimen of Campath, Fludarabine & Cytoxan. Doing great. 100% engraftment. No GVHD.
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