Quote:
Originally Posted by paulaespada
Can I ask you which cyclosporine dose is your husband on?
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Paula, for the last 3 1/2 years, he has been taking 175 mg of Gengraf per day (100mg in the morning, 75mg in the evening). He weighs about 175 lbs, so about 1 mg/lb of body weight? This is somewhat less than the maximum therapeutic dose, but he can't tolerate any more for very long without it affecting his kidneys. He has to drink LOTS of water too, which was hard to get him to do at first, but now that he's seen the results he's gotten used to it.
They initially started him out at 900 mg/day, which was much too high, and he had lots of unpleasant side effects. Over the next several months we gradually lowered it to 200 mg/day, but when he went in for his second ATG they briefly raised it to 300 mg/day during his treatment. They were also able to give him much less prednisone than they had the first time, since they had a better idea of how he would respond to it. As a result, his recovery time was much quicker the second time around.