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Old Thu Aug 21, 2014, 07:00 PM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Hi Sally,

I am going to respectfully counter-argue

Campath is a heavy-duty immune suppressant. Although your husband's marrow may not have been able to recover on its own after the treatment, I can still make the argument that it may have stopped the immune attack. If your husband didn't have the Campath, it is unclear whether he would have had the same result with eltrombopag alone. I am theorizing that his marrow needed the eltrombopag to kick start it into making blood cells again. Of course, I have no proof of this theory and am just basing it on what I am heard/read. If I am wrong, it wouldn't be the first time!

I remember some NIH presentations that talked about positive results from using eltrombopag for refractory AA that didn't respond to IST. They didn't talk about using it as a first line of treatment though.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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